Readings

Almost daily we hear about the impact of genomics on healthcare and how gene-directed diagnosis and therapies are transforming our understanding of widely divergent fields of biology and medicine.

Here I share with you some of the stories from the last year that I found particularly interesting. These stores exemplify the extent to which genomics is going to change the lives of patients and healthcare professionals.

Lecture 1: Reading homework assignment

Lecture 4: Guide to reading primary research articles

• CRISPR might not work in people

• DNA Snakes and Ladders

• Editing the Embryo

• DIY Crispr: biohacking your own genome

• Direct-to-consumer testing

• Who has the right to know your genetic test results?

• Older fathers pass on more mutations

• Calling cancer's bluff with neoantigen vaccines

• The increasing cost of cancer therapies

• Can genomics help detect early cancer and monitor treatment effectiveness?

Topics for class presentation and discussion:

• How useful are genomic approaches to solving mystery genetic diseases?
• How can your genome directly help guide drug treatments for treating disease?
• Can genetic testing be used to predict sports performance and injuries?
• Can genetic testing and genome editing be useful for choosing healthier embryos and producing designer babies?
• How will increased understating of epigenetics impact health care?
• How does the microbiome affect health and can it be rationally altered to improve health?
• Can people be identified solely from their genome sequence and if so what are the implications?
• Will having my genome sequenced affect my family members?
• Who has the right to know your genetic test results?

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